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(Listed by Principal Investigator)
Adgate, John
How Much is Too Much to Wheeze: Asthma Clinical Assessment and Standardized Allergen Sampling
11/15/2007 - 11/14/2010
Boston Medical Center (HUD prime)
The study will investigate three leading allergen sampling methods to determine which one(s) correlate best with asthma clinical status to provide the field evidence base needed for method standardization.
Alexander, Bruce H.
New Strategies for Follow-Up and Detailed Study of Radiation, Genetic Factors, and Risk of Cancer and Benign High Risk Conditions (USRT Cohort Study)
8/15/03 - 5/31/10
NIH/NCI
This study of a cohort of 146,000 registered radiologic technologists will examine the risks associated with chronic low-level occupational radiation exposure and cancer, genetic factors that may modify these risks, and whether benign conditions contribute to cancer risk in this population.
>>View U.S. Radiologic Technologists Study website
Spring House Worker Health Study
5/1/2008 - 4/30/2010
The Dow Chemical Co.
An "all cause" mortality assessment of workers at a chemical research
facility will be performed. The cohort will consist of workers who
spent a year or more at the facility starting in the early 1960s. The
mortality assessment will be supplemented by a detailed exposure
assessment of exposures in the research facility. Observed disease
rates will be compared to expected rates in the surrounding counties
and within the state where the facility is located.
Cancer Incidence in 3M Chemical Workers
03/01/2008 - 02/28/2011
3M
This project will evaluate the risk of cancer associated with occupational exposure to ammonium perfluorooctanoate (APFO) with specific emphasis on cancer of the prostate.
Medical Validation and Blood Collection Support for Studies of Cancer Risk in U.S. Radiologic Technologists
09/15/2009 - 09/14/2010
NIH
This project is being conducted in conjunction with the United States
Radiologic Technologists Study. The purpose of this effort is to
validate self-reported skin cancers for an analysis of the combined
effects of occupational ionizing radiation and ultraviolet radiation
exposure. It will also obtain biological samples from a sample of the
cohort for studies of biological markers and cancer and other health
conditions in relation to ionizing and ultraviolet radiation exposure.
Brosseau, Lisa M.
A Randomized Intervention in Auto Collision Repair
08/01/2007 - 07/31/2010
Park Nicollet Institute
This project will test the effectiveness of occupational health and safety interventions in small autobody collision repair shops.
An Integrated Work Safety - Smoking Cessation Program
02/01/2008 - 07/31/2009
ClearWay Minnesota
The proposed project is a collaboration between Carver County Public Health (CCPH) and University of Minnesota (UMN) researchers to develop and pilot-test an integrated smoking cessation (SC) / occupational health and safety (OHS) program for small and medium sized manufacturing worksites.
Aspen Research Project
04/28/2008 - 12/31/2009
Aspen Research Corporation
The goal of this project is to provide support for projects that
require
assessment of particle release and airborne particle concentrations.
Church, Timothy R.
Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
09/30/1992 - 09/29/2011
NCI/NIH
A 19-year collaborative multi-site randomized screening trial to determine if screening for four cancers will result in a significant reduction in cancer-specific mortality.
>>View Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial website
National Lung Screening Trial (NLST)
07/01/2002 - 06/30/2011
NCI/NIH
A collaborative, multi-site randomized screening trial, the primary objectives of which are to determine the mortality-reducing screening. effect and the benefit-to-risk ratio for spiral CT screening compared to chest x-ray.
>>View National Lung Screening Trial website
Validate MSK CISNET Colon Model with PLCO Data
09/01/2008 - 08/31/2010
Memorial Sloan-Kettering Cancer Center (NIH Prime)
Validate Memorial Sloan-Kettering's CISNET colon models using data from the PLCO trial.
Prospective Evaluation of SEPT9 Performance for Colorectal Cancer
09/01/2008 - 02/28/2010
Epigenomics, Inc.
Epigenomics has devised a blood test to screen for colorectal cancer
that they wish to test on human subjects. They wish to contract with
UMN-EnHS to recruit and obtain blood samples for 2105 individuals who are already planning to have colonoscopies and forward them to Epigenomics as part of their sample of 7,500 individuals.
PLCO Lymphoma Chromosomal Translocations
07/16/2008 - 10/31/2009
NCI/NIH
This project will attempt to secure 18 paraffin blocks from tumors of
Prostate, Lung, Ovarian and Colorectal Study (PLCO) participants for use in the Chromosomal Translocations in Non-Hodgkin Lymphoma in the PLCO Etiology Cohort Study.
Colorectal Cancer Family Registry
08/01/1997 - 06/30/2009
University of Southern California (NIH Prime: Haile)
This project will continue the stimulation of a collaborative effort for the establishment of a cooperative family registry for epedemiologic and interdisciplinary study of individuals at high risk for colorectal cancer.
>>View
Colorectal Cancer Family Registry (USC Consortium) website
Screening Colonoscopy Feasibility Trial
06/01/2003 - 04/30/2012
Memorial Sloan-Kettering (NIH Prime)
The primary goal of this study is to measure the impact of screening colonoscopies on the incidence and mortality rate of colon cancer in the study population.
>>View
Screening Colonoscopy Study website
Colorectal Chemoprevention with Calcium and Vitamin D
12/01/2002 – 07/31/2013
Dartmouth (NIH Prime)
The major goal of this clinical trial is to clarify the synergistic and independent chemopreventive effects of both vitamin D and calcium on the development of colon polyps. Epidemiological and experimental data indicate that both exert anti-neoplastic effects in the large colon.
>>View Colorectal Chemoprevention with Calcium and Vitamin D website
Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
01/02/2008 - 07/31/2009
Emory University (NIH Prime)
The goal is to investigate the efficacy of calcium and vitamin D in modulating a panel of molecular biomarkers of risk for colorectal cancer and determine whether this modulation predicts reduced recurrence of colorectal cancer.
Gerberich, Susan
Consequences of Agricultural Injuries among Children
07/01/2006 - 06/30/2011
NIOSH
The major goals are to identify the physical, psychosocial, and economic consequences of injuries that occur among children and youths living in agricultural operation households, in a five-state region, using a unique design that enables examination of potential changes between baseline and follow-up data, comparing injured and non-injured households and controlling for important factors including injury/illness experience among other household members.
Hedberg, Craig W.
Foodborne Disease Surveillance Cost Benefit Analysis
01/01/2009 - 12/31/09
Association of Public Health Laboratories(APHL) / CDC prime
This project will document costs and benefits of the PulseNet system and associated foodborne disease epidemiology programs at multiple jurisdictional levels. Costs of the system are incurred at CDC, State Public Health Departments, Local Public Health departments, hospital and private laboratories, and by individual healthcare providers. Benefits are to the public at large through (1) short term prevention of ongoing transmission through direct public health action, such as food recall or closing of a restaurant, and (2) long term prevention of disease through changes in food practices.
Evaluation of Cluster Definitions for Foodborne Outbreak Investigations
02/01/2008 - 07/31/2009
Council Of State And Territorial Epidemiologists (CSTE)
/CDC Prime
This project will define the key factors that drive the success of "local cluster" investigations for E. coli O157:H7 and Salmonella from a state perspective in five "model" states and from a national perspective for "multi-state clusters".
>>View Evaluation of Cluster Definitions for Foodborne Outbreak Investigations website
Conversion of Curriculum for Food Safety and Food Defense
Certificate from In-Class Delivery to Distance Learning Format
09/01/2007 - 05/31/2008
NCFPD
In order to make the Regent’s Certificate Program in Food Safety and Biosecurity more widely available to health professionals, food regulatory officials and food defense specialists in industry we are converting the food defense courses currently offered through the Public Health Institute into a distance learning format, available for credit on-line through the University of Minnesota.
Mandel, Jeffrey
Health Assessment of Taconite Workers
07/01/2008 - 06/30/2011
State of Minnesota
This project consists of three health components and a comprehensive
occupational exposure assessment. The health components include a cohort mortality study of taconite workers (approximately 72,000) employed between 1953 and 1984, looking at rates of specific diseases for all causes of death within the cohort compared to state and national rates.
Another component includes a cancer incidence study with a focus on mesothelioma cases, identified through the state's cancer surveillance system. A final component includes a cross-sectional screening of current and former taconite workers and their spouses. This effort involves the identification of non-cancerous lung disease in these workers and their spouses. All three of these components will be supplemented by information obtained through a comprehensive occupational exposure assessment, which will emphasize exposures to dusts generated in the mining process.
>>View Minnesota Taconite Workers Lung Health Partnership website
Taconite Pre-Screening Study
06/01/08 - 12/31/09
Iron Range Resources (IRR)
This project will help establish tactical and strategic approaches for a
larger respiratory health screening effort that will be conducted for
current and former taconite workers and their spouses. Focal group
discussions will be used to assess logistical and tactical issues of the
actual screening process. Results from these discussions will maximize
the screening efficiency and effectiveness. Focal group discussions
will be conducted in late 2008. Results will be applied to the
respiratory screening process scheduled to begin later in 2009.
Spring House Worker Health Study
5/1/2008 - 4/30/2010
The Dow Chemical Co.
An "all cause" mortality assessment of workers at a chemical research
facility will be performed. The cohort will consist of workers who
spent a year or more at the facility starting in the early 1960s. The
mortality assessment will be supplemented by a detailed exposure
assessment of exposures in the research facility. Observed disease
rates will be compared to expected rates in the surrounding counties
and within the state where the facility is located.
McGovern, Patricia
National Children’s Study (NCS): Ramsey Location
09/28/2007 - 09/28/2012
NIH/NIDDK
The goal of this study is to develop a Study Center for the National Children’s Study (NCS) that will serve an identified base location, Ramsey County, Minnesota. The NCS is a longitudinal cohort study to examine environmental influences on child health and development. The Ramsey County location will enroll a probability sample of approximately 1000 women, and where feasible, their partners, to assess exposures and personal characteristics pre-conception and prenatally, as part of the national cohort. Children will be followed for health and developmental outcomes and environmental exposures.
>>View National Children's Study - Ramsey Location - University of Minnesota website
Peterson, Lisa A.
Role of O 6 -alkylguanine in nitrosamine-induced cancers
04/01/05 - 03/03/10
NIEHS/NCI
This project will investigate the role of formation and repair of bulky O 6 -alkylguanine adducts in the mutagenic and carcinogenic properties of environmental nitrosamines.
Role: PI
Ramachandran, Gurumurthy
Development of Environmental Health Outcome Indicators: Impact of Emission Reductions on Exposures and Exposure Distributions: Application of a Geographic Exposure Model
09/01/2007 - 10/31/2010
EPA
The exposure and health impacts of a given level of emission reductions will, in general, vary among sources (e.g., cars versus power plants). This project will investigate how emission reductions from various sources would impact (1) the population-average exposure level, and (2) the distribution of sources among income and ethnic subpopulations. We employ an existing mobility-based exposure model for ~ 25,000 people in Los Angeles and other areas of California's South Coast Air Basin.
Role: Co-PI
Raynor, Peter
Effects of Spray Surfactant and Particle Charge on Respirable
Dust Control
09/15/2009 - 09/14/2012
NIOSH
The objective of this project is to evaluate how efficiently sprays containing different types and concentrations of surfactants collect coal dust particles carrying various signs and magnitudes of electrostatic charge. A laboratory test apparatus will be used to measure the efficiency with which sprays containing different types of surfactants collect particles charged negatively, positively, or in a bipolar manner.
Assessing Potential Nanoparticle Release During
Nanocomposite Recycling
09/01/08 - 12/21/09
U.S. Council for Automotive Research (USCAR)
The goal for this research is to ensure that workers involved in recycling nanocomposite components from automobiles do not receive harmful exposures to airborne nanoparticles emitted from the parts. In this study, we will use a variety of sampling instruments and analytical techniques to evaluate airborne particles generated as a granulator shreds nanocomposite test plaques and similar test plaques that do not contain nanoparticles. We will compare the data from the different test plaques to determine the potential for the nanocomposites to release nanoparticles.
Pollution Prevention and Energy Efficiency for Minnesota's Metal
Fabrication and Machining
10/01/08 - 03/31/10
EPA
This project is part of a longer range program objective to minimize the impact of metal fabrication waste on the environment and to develop strategies to help engineers understand the impact of their work on public health and the environment. The objective of this application is to identify and implement source reduction and energy efficiency opportunities in metal fabrication.
Simcik, Matt
FoodWeb Dynamics and Source/Sink Interaction of
Perfluorochemicals in a Minnesota Lake
05/12/08 - 10/30/09
MN Pollution Control Agency
The purpose of this study is to analyze the perfluorochemical (PFC) levels of a St. Paul suburban lake via a comprehensive sampling of the lake’s “food web”. Researchers will collect soil, sediment, plant life, as well as the full range of animal species, including insects, fish, and frogs to build a better idea of how perfluorochemicals behave and accumulate.
Toscano, Jr., William A.
Minnesota Technical Assistance Program
11/01/1984 - 06/30/2010
MN Pollution Control Agency
Assist Minnesota businesses with pollution prevention and waste management information, facilitate implementation of improved practices through on site assistance, provide referral for compliance with environmental regulations, and minimize transfer of pollutants from one environment to another.
>>Minnesota Technical Assistance Program website
Pollution Prevention and Energy Efficiency for Minnesota's Lodging Industry
10/01/2009 - 03/31/2011
EPA
This project is part of a longer range program objective to minimize the impact of waste from the hospitality sector on the environment. The specific objective of this application is to identify and implement source reduction and energy efficiency opportunities that will reduce wastewater loading, solid waste, water use, and energy use. This will be accomplished by holding two industry stakeholder meetings (large and small hotels), conducting site assessments at hotels, documenting the impact of this work on the environment, and conducting a pilot that will lead to development of a Green Lodging Certification in Minnesota.
Non-Hospital Healthcare Sector Outreach
Period
10/01/09 - 09/30/10
MN Pollution Control Agency
This project will provide outreach and assistance to non-hospital
healthcare facilities in MN including health and veterinary clinics,
pharmacies, and nursing care facilities. MnTAP will partner with MPCA
and metro counties to provide educational resources, training
workshops,on-line self assessments, and site visits. Desired outcomes
are reduced waste, increased compliance and cost savings.
Researching Energy Conservation Potential for Minnesota Business
and Industry
09/30/08 - 09/30/10
MN Department of Commerce
This project is to help utilities meet their 1.5% annual energy savings
goal by assisting Minnesota business and industry to become more energy efficient. To achieve this objective, MNTAP will conduct five industrial market sector analyses to identify sector-specific energy efficiency opportunities for six investor- owned utilities.
Reducing Waste from Medical Device Manufacturing
10/01/2007 - 09/30/2009
EPA
This project is part of a long rage program to minimize the impact of medical device manufacturing on the environment, and to develop strategies so engineers understand the impact of their work on public health and the environment. The specific objective of this grant is to educate medical device component manufacturing staff to identify and implement source reduction opportunities that will reduce waste including hazardous waste.
Pollution Prevention Opportunity Assessments
09/29/2008 - 09/28/2009
MN Department of Military Affairs
Assist Minnesota Army National Guard in updating and expanding pollution
prevention plans for its operations.
Load Reduction to Minnesota POTWs Using Pollution Prevention
07/01/2007 - 06/30/2008
MN Pollution Control Agency
MnTAP will provide pollution prevention technical assistance to publicly owned treatment works and industrial users for nutrient, mercury and other pollutant reduction.
Wattenberg, Elizabeth V.
Negative Regulators: Key Determinants in Carcinogenesis
03/1/2005 - 02/28/2010
NIH
The major goal of this study is to investigate the novel concept that phosphatases involved in a negative feedback loop that constrains Ras-stimulated signaling are vulnerable targets during early stages in carcinogenesis.
Genomic Profiling of Signaling Network in Cancer Cells
08/13/2009 - 08/12/2010
Minnesota Medical Foundation (MMF)
The purpose of this study is to obtain pilot data, via microarray analysis, which is required to investigate the regulation of essential cellular processes that are key determinants of health and disease. Cell fate and function are regulated by a network of signaling pathways. Cancer is characterized at the cellular level by aberrant regulation of such signaling pathways and networks.
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