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Introduction
Characteristic of the Agent
Fate and Transport
Environmental Impacts
Environmental Monitoring
Exposure Pathway
Methods for Measuring Human Exposure
Routes of Exposure
Strategies for Preventing or Controlling Exposures
Harmful Effects
Dose Response
Absorption, Distribution and Metabolism
Biomarkers
Target Organs and Tissues
Mechanisms of Toxicity
Risk Assessment and Risk Management
References
5103/5104 Home
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Strategies for Preventing or Controlling Exposures
- Total Elimination of Plasticizer compounds use in products
-Not likely due to our dependence/benefits of flexible plastics
Net Societal Benefit
-Requires Legislation for compliance
- Substitution of less harmful substances
-One example is using a 3 layer polypropylene in blood bags which gives the needed softening, but yet keeps the barrier protection
Case Study XVI: Miller Children Hospital (Long Beach, CA)
-Eliminated IV sets that contained DEHP
-Total projected cost was $20,000 or ~$20 per patient
-Other known substitutes (depending on the product) include silicon, polyurethane, polyethylene and nylon.
- Reduction of quantity of phthalates used. Either:
- reduce the amount in specific product recipes
- reduce the total number of products with phthalates added
- Mandate appropriate disposal of products containing phthalates
- reduces materials being incinerated/land filled potentially
reducing inhalation/ingestion exposures
- public education needed
- Possible effluent technology in industrial sector, reducing emissions
- Bioremediation of DEHP
-Microbes have been shown to degrade compound in weeks XII
- Photodegradation of DEP
- Water treatment methods approved by EPA for removing phthalates using Granular Activated Charcoal XVII
- Using alternative sources of drinking water when your area has known levels of phthalate (DEHP) to exceed the Maximum Contaminate Level (MCL) of 6 ppb XVII
- Respirator use in the occupational setting, reducing the intake of air pollutants. Other occupational changes include process enclosure and ventilation where phthalate fumes are shown in increased levels
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